AI Was Supposed To Cure Everything By Now, What’s Actually In The Way? (An Engineer’s Perspective)

Google's AlphaFold won a Nobel Prize for revolutionizing biology...so why is the successor locked behind closed doors? An engineer's breakdown of the science, biosecurity concerns, and why our most altruistic AI isn't publicly available. My controversial take: you can't hate AI until you understand it, so let's change that by doing a deep dive into a little corner of it. Today we take a deep-dive look at the AI that just replaced the Nobel Prized AlphaFold model and learn why the company behind its successor refuses to let anyone touch it (wtaf?). We'll also tackle unphysical hallucinations, how a flip-flopped molecule can turn a cure into a poison, and NeuralPLexer3: the model that's "too good" to release. NOTE: All of my videos, despite being on the topic of AI and Machine Learning, are 100% human made, including scripting, editing, and audio. We are interested in positive applications of Machine learning on this channel, and imo that doesn't include creative uses for AI. Humans are for creating. * (This doesn't include any AI pre-generated images that I use as examples of AI generated images, and they are not images I've ever generated myself.) Video Timestamps: 0:00 Intro 1:50 How Proteins Work 3:54 Levinthal's Paradox 4:22 CASP 5:25 Is AlphaFold Dead? 6:02 NP3 (Neural PLexer3) 7:27 Unphysical Hallucinations 10:20 AI Uncanny Valley 11:40 NP3 Decoded 14:46 How Do We Know It Actually Works? 15:42 The Results 16:17 The Trade-Off 17:35 Apo and Holo States 18:22 Cryptic Sites 20:15 Kinases 21:14 What's the Cost? 26:08 The Biosecurity Lockdown 27:16 Limitations 27:47 My Question for You primary sources: https://docs.google.com/document/d/11pafLrYT7ZXJ_7eVvy_GreYqJTS6Yp8qUcGaIU8rsso/edit?usp=sharing 🕯️ Subscribe to come with me. 🥹 My app waitlist: https://www.vyhr.app 📜 Substack (Written Essays): https://substack.com/@rhytomlin 📸 The Visuals: https://www.instagram.com/rhytomlin/ 🪶 CONTEXT I started a company a 8 months ago. I thought being a Founder meant drinking coffee and picking aesthetic fonts. HAHA, what a joke. This definitely isn't a "How To" guide. It's a sort of Lab Notebook, the intellectually messy documentation of building a tech startup from scratch, while aiming to consistently prove that direction beats intensity. Rhy Tomlin v1.0 (startup mode) ABOUT I’m Rhy. The Tech Eldest Daughter (graduate degree in CS, ex-EV industry) who reads Romantasy in between debugging sessions. My mission is to help democratize success by reverse-engineering it (but at the beginning 🙃). I refuse to outsource my curiosity, and I document the messiest middle of building a startup because I believe (some) struggle is the only way to make it useful (and worthwhile, duh). I’m not here to hand out "3 tips to get 6 sales.", okay? I’m here to hand you the schematics as I'm sketching them out so that we can pull the ladder down together. FAQ: What's the app? A personalized mindset tool for people who want to engineer their way through self-limiting beliefs. Current Read: A Tongue so Sweet and Deadly by Sophia St. Germain 📚 Language: Swift Backend: Firebase Design: Figma CMS: Sanity Editor: VS Code (Dracula Theme, obviously) XCode (when I have to 😭)